Molecular Interaction between COP1 and HY5 Defines a Regulatory Switch for Light Control of Arabidopsis Development
نویسندگان
چکیده
منابع مشابه
Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development.
Arabidopsis COP1 acts as a light-inactivable repressor of photomorphogenic development, but its molecular mode of action remains unclear. Here, we show that COP1 negatively regulates HY5, a bZIP protein and a positive regulator of photomorphogenic development. Both in vitro and in vivo assays indicate that COP1 interacts directly and specifically with HY5. The hyperphotomorphogenic phenotype ca...
متن کاملThe roles of photoreceptor systems and the COP1-targeted destabilization of HY5 in light control of Arabidopsis seedling development.
Arabidopsis seedlings display contrasting developmental patterns depending on the light environment, e.g. photomorphogenesis in the light and skotomorphogenesis (etiolation) in darkness. Recent studies have implicated protein degradation as a means of regulating this developmental switch (Osterlund et al., 2000). For example, HY5, a positive photomorphogenic regulator that acts to promote the l...
متن کاملThe COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity.
Arabidopsis COP1 is a constitutive repressor of photomorphogenesis that interacts with photomorphogenesis-promoting factors such as HY5 to promote their proteasome-mediated degradation. SPA1 is a repressor of phytochrome A-mediated responses to far-red light. Here we report that COP1 acts as part of a large protein complex and interacts with SPA1 in a light-dependent manner. We further demonstr...
متن کاملLight regulated modulation of Z-box containing promoters by photoreceptors and downstream regulatory components, COP1 and HY5, in Arabidopsis.
The Z-box is one of the light-responsive elements (LREs) found in the promoters of light inducible genes. We have studied the light responsive characteristics of Z-box containing synthetic as well as native promoters. We show that promoters with Z-box as a single LRE or paired with another LRE can respond to a broad spectrum of light. The response is primarily mediated by phyA, phyB and CRY1 ph...
متن کاملDirect interaction of Arabidopsis cryptochromes with COP1 in light control development.
Arabidopsis seedling photomorphogenesis involves two antagonistically acting components, COP1 and HY5. COP1 specifically targets HY5 for degradation via the 26S proteasome in the dark through their direct physical interaction. Little is known regarding how light signals perceived by photoreceptors are transduced to regulate COP1. Arabidopsis has two related cryptochromes (cry1 and cry2) mediati...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 1998
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)80022-2